Nate Navigato hit three 3-pointers and finished with 15 points, five rebounds and four assists for Toledo (19-7, 11-2 Mid-American Conference).
Fletcher, Marreon Jackson and Navigato each hit a 3-pointer during a 15-0 opening run and the Rockets led the rest of the way. Kevin Mickle's jumper pulled Ohio (10-15, 3-10) within six points with three minutes to play, but Toledo hit 15 of 16 free throws from there to seal it.
Mickle, a graduate transfer from Florida Gulf Coast, led Ohio with a career-high 24 points on 10-of-19 shooting. Teyvion Kirk added 21 points - including 19 in the second half - and 10 rebounds.
Toledo made 32 of 37 free-throw attempts - both season highs.
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