Not a whole lot went right after that for Hutchison and the struggling Toronto Blue Jays.
David Ortiz hit the 452nd and 453rd homers of his career, moving past Boston great Carl Yastrzemski into 36th place on the all-time list, and the Red Sox won their fifth straight game, routing Toronto 14-1.
"The best thing about it is it's over with," Blue Jays manager John Gibbons said.
Toronto lost for the 10th time in 14 games. They have scored three runs or fewer in nine of those 14.
Hutchison (6-9) matched a career high with six earned runs, the second straight outing he allowed that many, and gave up a career-high nine hits in 2 2-3 innings, his shortest non-injury start.
"I felt good," Hutchison said. "I just didn't get the job done."
Hutchison, who lost for the first time in three outings against Boston, fell to 2-5 with a 7.71 ERA in eight home starts.
"Hutch looked really good and then from there on they didn't miss him," Gibbons said.
Ortiz matched Yastrzemski with a two-run blast to center off left-hander Brad Mills in the fourth, then broke the short-lived tie with another two-run shot off Mills in the fifth, his 21st and 22nd homers of the season.
"He's always hit well in this ballpark and tonight was another example," Red Sox manager John Farrell said of Ortiz, whose 35 career homers at Rogers Centre are second only to Alex Rodriguez's 36.
It was the third multihomer game of the season for Ortiz and the 44th of his career.
Ortiz's first homer ended his 0-for-18 skid against Toronto and an 0-for-11 slump overall. He went 1 for 13 in Boston's weekend sweep of Kansas City.
"He's a Hall of Famer in my eyes," said Mike Napoli, who followed Ortiz's second shot with his 12th homer, the fourth time this season Boston has gone back-to-back.
Stephen Drew added a three-run homer as the Red Sox connected a season-high four times and won for the eighth time in nine games.
Dustin Pedroia was the only Boston starter without a hit as the Red Sox set season highs in runs and hits (18). Pedroia went 0 for 4 before being replaced and is hitless in 13 at-bats.
John Lackey (11-6) allowed one run and two hits in seven innings to win his second straight start. Felix Doubront worked the eighth and Craig Breslow finished.
"We couldn't do anything with Lackey at all but when you fall that far behind that's usually the case," Gibbons said.
The Red Sox took the lead with two runs in the second and added four in the third, chasing Hutchison. Boston blew it open with two more in the fourth and six in the fifth against Mills.
Boston's Brock Holt made the defensive play of the game, leaping into the right field wall to retire Dan Johnson for the first out of the fifth.
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